Cellular energy · Methylation · Nerve health

Methyl B6 + B12

Quatrefolic®·See why we use it →

★★★★★ 4.8 (1,010 reviews) Third-party tested 100+ studies independent

The Methyl B6 + B12 bottle held in a real hand against a soft limestone background, cap just opened. Warm side light, shallow focus, adult and unhurried.

One Quatrefolic® dose and a glass of water on a stone bathroom counter, morning light. The product in its daily moment — calm, clean, no clutter.

Amber Quatrefolic® softgels poured from the bottle into an open palm in warm morning light — the daily dose, in real hands.

Dose VerifiedStudy VerifiedLot Verified

Third-party tested →

Non-GMO · Gluten-free · Made in USA

SourcedDesio, Italy

MadeLindon, Utah

TestedBellingham, WA

1,000 mcgthe exact dose the studies used

100+ studiesindependent, peer-reviewed

3×tested before any lot ships

60-daymoney-back guarantee

The difference

What makes it different

Active, methylated forms

No synthetic folic acid or B12 to convert.

Quatrefolic® folate

The patented active 5-MTHF.

Sensibly dosed

Amounts that work, not megadosed.

Made in the USA

Third-party tested for potency.

Field note

A lot of people take a B-complex and feel nothing, because their body can't convert the cheap synthetic forms well. Ours are already in the active form, so your body skips the conversion step. Start low if you run anxious.

What it's good for

What it supports

Because we use Quatrefolic® — the exact ingredient and the exact dose the studies used, not a cheaper generic — we can stand behind what that research shows it supports:

✓

Cellular energy

B12 and B6 sit at the center of how cells make usable energy.

✓

Homocysteine metabolism

Methylated B's support healthy homocysteine levels.

✓

Nerve & cognition

Supports nerve health and everyday mental clarity.

✓

Methylation

Active forms for the roughly 40% who convert the synthetics poorly.

These are structure/function statements based on published studies of the ingredient, not on this finished product. They have not been evaluated by the Food & Drug Administration, and this product is not intended to diagnose, treat, cure, or prevent any disease.†

What's in it1,000 mcg active The full supplement facts: 1,000 mcg of Quatrefolic®, what carries it, and nothing else. No proprietary blends, no fillers.

What's inside

Serving SizeSee directions

Amount Per Serving

Vitamin B6 (as Pyridoxal-5-Phosphate)10 mg

Folate (as L-5-MTHF, Quatrefolic®)400 mcg DFE

Vitamin B12 (as Methylcobalamin)1,000 mcg

Other ingredients: vegetable cellulose capsule. No proprietary blends, no fillers we can't justify. Free of gluten, dairy, soy, and GMOs. † Daily Value not established for some ingredients.

Directions

One capsule daily, with breakfast.

A lot of people can't convert synthetic folic acid and B12 well — the body has to do the work, and many can't. We use the active forms instead: methylcobalamin, P-5-P, and Quatrefolic® 5-MTHF. No synthetics to convert. Made in the USA and third-party tested.

10 mgVitamin B6 (as Pyridoxal-5-Phosphate)

400 mcg DFEFolate (as L-5-MTHF, Quatrefolic®)

1,000 mcgVitamin B12 (as Methylcobalamin)

0Proprietary blends or fillers we can't justify.

The research100+ studies 100+ studies on Quatrefolic®: what they found, with every citation linked so you can read it yourself.

We don't make the claims. The studies do. 100+ studies on Quatrefolic® — read every one yourself.

The studies behind it

[01] 5-MTHF bioavailability vs folic acid Pietrzik et al., 2010 — Clinical Pharmacokinetics Read the study → [02] Homocysteine metabolism Verhoef et al., 2005 — American J. Clinical Nutrition Read the study → [03] Homocysteine lowering (meta-analysis) Clarke et al., 2010 — Archives of Internal Medicine Read the study → [04] Active folate absorption Prinz-Langenohl et al., 2009 — British J. Pharmacology Read the study → [05] B12 & cognitive function Smith et al., 2010 — PLOS ONE Read the study → [06] Methylcobalamin & nerve health Zhang et al., 2013 — Journal of Neurology Read the study →

Citations refer to published, peer-reviewed research on the ingredient — not on this finished product. Structure/function statements only, not evaluated by the FDA.† See all studies for Methyl B6 + B12 →

Where it comes fromSourced → made → tested From Desio, Italy to your bottle. Every stage named, made in the USA, third-party tested before it ships.

01Sourced

Desio, Italy

Quatrefolic® 5-MTHF, the patented active folate, made by Gnosis in Italy.

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02Formulated

Lindon, Utah, USA

Paired with methylcobalamin B12 and P-5-P — no synthetic stand-ins.

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03Made

Lindon, Utah, USA

Encapsulated and bottled in an NSF-registered, cGMP facility.

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04Verified

Third-party lab

Tested for identity and potency of each active form.

Tested by the supplier → then in-house → then a third party

How we test every lot →

Order specification

$22.10 $26 Save 15%

★★★★★4.8 · 1,010 reviews

What people say about Methyl B6 + B12.

4.8

★★★★★

Based on 1,010 verified reviews

5★78%

4★16%

3★4%

2★1%

1★1%

Dana R. ✓ Verified

★★★★★ · 2 months ago

The only brand whose label I don't have to fact-check. I emailed for the COA on my lot and they sent it the same day.

Transparency

Paul M. ✓ Verified

★★★★★ · 3 weeks ago

Switched from Thorne. Same rigor, the dose is actually printed on the front, and it's a better price.

Switched brands

Marian K. ✓ Verified

★★★★★ · 5 days ago

I'm 67 and tired of guessing what's in my supplements. This one prints everything. My pharmacist looked at the label and approved.

Trust

Priya S. ✓ Verified

★★★★☆ · 1 month ago

Took about six weeks, but I notice the difference now. I appreciate that they tell you to give it time instead of overpromising.

Patience

Greg T. ✓ Verified

★★★★★ · 2 weeks ago

No gut issues, no aftertaste. Finally a brand that doesn't cut corners to save a few cents.

Easy on the stomach

Tom B. ✓ Verified

★★★★★ · 2 months ago

Was skeptical about the price until I actually read the third-party test report. You get what you pay for.

Skeptic

Sofia A. ✓ Verified

★★★★★ · 3 months ago

Bought it for my dad. He reads labels obsessively, and this is the only one he trusts now.

Gifting

Devon L. ✓ Verified

★★★★☆ · 6 weeks ago

Two capsules a day, easy to take. Wish the bottle were a touch bigger, but the quality is clearly there.

Daily use

Renee W. ✓ Verified

★★★★★ · 1 month ago

Clean, no fillers, and they answer emails like actual humans. Already re-ordered.

Service

Hassan M. ✓ Verified

★★★★★ · 3 weeks ago

The dose matches the studies they cite. That's the whole reason I bought it, and it delivered.

Studied dose

Sample reviews shown for design purposes.

FAQ

Does any of this actually work, or is it expensive pee?

Fair question. We only sell ingredients with human studies behind them, and we link every one. If your body doesn't need a nutrient, you'll pass it — so we tell you who each product is actually for.

How do I know it isn't underdosed?

We make one ingredient per product, at the amount the studies used, printed right on the front. There's no blend to hide a pinch behind.

What does “tested three times” mean?

The supplier tests it, our own lab tests it again, then an independent lab tests the finished batch — for potency, heavy metals, and microbes. Email us your lot number and we'll send the report.

If it's sourced abroad, how is it Made in the USA?

We buy each ingredient from wherever it's made best — Italian olive oil, Spanish saffron, Japanese fermentation. Every product is then made and bottled in Lindon, Utah.

I've tried things like this before and felt nothing.

Most of these studies run 8 to 12 weeks, so give it that long. If you still feel nothing, send it back within 60 days, opened or not, and we'll refund you.