The active, methylated form of folate, with active B12 and B6 — the forms your body can use without converting them first.
Quatrefolic® 5-MTHF, the patented active folate, made by Gnosis in Italy.
Why here: it's where this ingredient is genuinely best. We audit the supplier, then bring it to the USA to be made and tested.
Quatrefolic® 5-MTHF, the patented active folate, made by Gnosis in Italy.
Paired with methylcobalamin B12 and P-5-P — no synthetic stand-ins.
Encapsulated and bottled in an NSF-registered, cGMP facility.
Tested for identity and potency of each active form.
100+ studies on Quatrefolic®.
Because we use Quatrefolic® — the exact ingredient and dose from these studies, not a cheap generic — the research proves:
These are structure/function statements based on published studies of the ingredient — not on this finished product, and not a promise about any one person. Not evaluated by the FDA.†
Citations refer to published, peer-reviewed research on the ingredient — not on this finished product. Structure/function statements only, not evaluated by the FDA.† See all studies for Methyl B6 + B12 →
B12 and B6 sit at the center of how cells make usable energy.
Methylated B's support healthy homocysteine levels.
Supports nerve health and everyday mental clarity.
Active forms for the roughly 40% who convert the synthetics poorly.
These describe what the ingredient has been studied for — not a promise about you. Talk to your doctor before starting anything new.
B vitamins in the active form your body can use right away. No cheap synthetics to convert.
Shop Methyl B6 + B12 — $22.10 →